Words about science and hiking
I admit to doing a spit-take when I saw the title of this article: Aptamers as Therapeutic Agents: Has the Initial Euphoria Subsided?. At this stage in the game, with only one aptamer therapeutic cleared and it having perennially weak sales, that question mark in the title seems more than a bit out of date. Read More …
RNA therapeutics have been around for a long time. Stanley Crooke founded Isis Pharmaceuticals (diplomatically renamed Ionis in 2015) in the late 1980s. They got an approval for treating CMV infections in AIDS patients in 1998 (a commercial flop)…and didn’t get a second approval until 2013. I don’t know the investment history of Isis, but Read More …
Disclosure up front: I helped found SomaLogic and was its first R&D director. I left the company in 2004, but exercised my options and still hold its stock. I am definitely not neutral about the value of proteomics as a diagnostic and prognostic platform. Last Sunday’s NYT magazine had a pretty good article about the Read More …