Tag: pharmacokinetics

RNA therapeutics: has the code been cracked?

Posted on1 Comment

RNA therapeutics have been around for a long time. Stanley Crooke founded Isis Pharmaceuticals (diplomatically renamed Ionis in 2015) in the late 1980s. They got an approval for treating CMV infections in AIDS patients in 1998 (a commercial flop)…and didn’t get a second approval until 2013. I don’t know the investment history of Isis, but Read More …

What we can learn from Megaphage

Posted on4 Comments

Giant viruses are cool. Their genomes are bigger than those of many bacteria (especially endosymbionts), and they encode many housekeeping functions that are not obviously necessary for the viral lifestyle. They blur boundaries between the neat little categories we use to describe biological entities and thus remind us that those categories are conveniences, not reality. Read More …