How do we use likelihood ratios?

Likelihood ratios are a good measure of the clinical value of a diagnostic test. Positive likelihood ratio = sensitivity/(1-specificity), where sensitivity is defined as the fraction of patients who have the disease and yield a positive test result, and specificity is the fraction of patients who do not have the disease and yield a negative Read More …

Will gene therapies ultimately become more prevalent than traditional drugs?

It is hard to imagine how this could happen. Let’s assume that all the technical obstacles that now plague gene therapy[1] are resolved. In other words, that we learn how to deliver genes efficiently to the appropriate tissues without any side effects. Gene therapy would still be appropriate for only a tiny fraction of human Read More …